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Corpus Systématique Végétale

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The effect of FCE 22891, a new oral penem, on faecal flora anaerobes and their fermentation end products in patients with chronic obstructive pulmonary disease

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  • G. J. Meijer-Severs Ph. D. 1
  • Edith van Santen B. Sc. 1
  • S. M. T. Puister M. D. 2
  • W. G. Boersma M. D., Ph. D. 2
  • 1) Laboratory for Medical Microbiology, State University of Groningen, The Netherlands
  • 2) Dept. of Pulmonary Diseases, University Hospital Groningen, Oostersingel 59, NL-9713 EZ, Groningen, The Netherlands

The influence of FCE 22891 on the faecal flora was investigated in 11 patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD). Colony counts of faecal (an)aerobes and concentrations of their short-chain fatty acids and organic acids were determined simultaneously in fresh faeces before, during and after administration of the drug, and compared to those of healthy human volunteers. The MIC of FCE 22891 for the 142 isolated anaerobes was determined, and compared to the biologically active concentration of the drug in faeces. TheBacteroides colony counts of the patients increased significantly by day 9 compared to day 3, but were significantly lower than those of the healthy controls before, during and after the study. Significant changes in short-chain fatty acids and organic acid concentrations occurred in faeces of the patients during and after treatment, and especially when compared to healthy controls. A strong increase in MICs during treatment was found inClostridium species, other thanClostridium difficile. FCE 22891 had only a moderate effect on the composition of the anaerobic faecal flora, but bacterial fermentation was mainly disturbed before and early on in treatment, which could have been caused by the disease.

Catégories Science-Metrix
  • 1 - health sciences
  • 2 - biomedical research
  • 3 - microbiology
Catégories INIST
  • 1 - sciences appliquees, technologies et medecines
  • 2 - sciences biologiques et medicales
  • 3 - sciences medicales
Catégories Scopus
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Infectious Diseases
  • 1 - Health Sciences ; 2 - Medicine ; 3 - Microbiology (medical)
  • 1 - Health Sciences ; 2 - Medicine ; 3 - General Medicine
Catégories WoS
  • 1 - science ; 2 - infectious diseases
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